Table 3 Comparing differences of mean change in outcomes at follow-up periods from baseline between the intervention group and control group
Outcomes | 4-week | 8-week | 12-week | 16-week | 20-week | Over 20 weeksb |
|---|---|---|---|---|---|---|
mean change (95% CI) | mean change (95% CI) | mean change (95% CI) | mean change (95% CI) | mean change (95% CI) | Difference mean change (95%CI) | |
Primary outcome | ||||||
 Body weight (kg) | ||||||
  Intervention | -0.6 (-1.2, -0.1) | -1.2 (-1.8, -0.5) | -1.1 (-1.9, -0.2) | -1.0 (-1.8, -0.1) | -1.2 (-2.2, -0.3) | -1.0 (-1.7, -0.2) |
  Control | -0.4 (-0.8, 0.1) | -0.5 (-0.9, 0.0) | 0.2 (-0.3, 0.7) | 0.3 (-0.2, 0.8) | 0.3 (-0.3, 0.8) | Ref |
  p-valuea | 0.459 | 0.680 | 0.008 | 0.009 | 0.007 | 0.015 |
Secondary outcomes | ||||||
 Body mass index (kg/m2) | ||||||
  Intervention | -0.3 (-0.5, 0.0) | -0.5 (-0.7, -0.2) | -0.5 (-0.8, -0.1) | -0.4 (-0.8, -0.1) | -0.5 (-0.9, -0.1) | -0.4 (-0.7, -0.1) |
  Control | -0.3 (-0.5, 0.0) | -0.2 (-0.4, 0.0) | 0.1 (-0.1, 0.3) | 0.1 (-0.1, 0.3) | 0.1 (-0.1, 0.3) | Ref |
  p-valuea | 0.401 | 0.052 | 0.007 | 0.007 | 0.006 | 0.012 |
 Waist circumference (cm) | ||||||
  Intervention | -1.0 (-3.3, 1.4) | -1.1 (-3.4, 1.2) | -1.4 (-3.4, 0.6) | 0.4 (-1.9, 2.7) | -0.4 (-3.0, 2.1) | -0.3 (-2.5, 1.9) |
  Control | 0.3 (-1.5, 2.1) | -1.8 (-3.4, -0.1) | -0.1 (-2.0, 1.8) | -0.7 (-2.5, 1.1) | -0.6 (-2.4, 1.2) | Ref |
  p-valuea | 0.374 | 0.614 | 0.335 | 0.434 | 0.900 | 0.805 |
 Waist to height ratio | ||||||
  Intervention | -0.01 (-0.02, 0.01) | -0.01 (-0.02, 0.01) | -0.01 (-0.02, 0.00) | 0.00 (-0.01, 0.02) | 0.00 (-0.02, 0.01) | 0.00 (-0.02, 0.01) |
  Control | 0.00 (-0.01, 0.01) | -0.01 (-0.02, 0.00) | 0.00 (-0.01, 0.01) | 0.00 (-0.02, 0.01) | 0.00 (-0.02, 0.01) | Ref |
  p-valuea | 0.374 | 0.578 | 0.346 | 0.445 | 0.920 | 0.807 |
 Systolic blood pressure (mmHg) | ||||||
  Intervention | -9.7 (-13.8, -5.5) | -5.0 (-8.9, -1.1) | -7.7 (-11.5, -3.8) | -4.1 (-8.7, 0.4) | -4.8 (-9.9, 0.4) | -3.9 (-8.6, 0.8) |
  Control | -4.1 (-7.9, -0.2) | -1.2 (-5.2, 2.8) | -1.8 (-6.0, 2.4) | -2.6 (-7.1, 1.9) | -2.3 (-6.2, 1.5) | Ref |
  p-valuea | 0.046 | 0.169 | 0.036 | 0.626 | 0.446 | 0.103 |
 Diastolic blood pressure (mmHg) | ||||||
  Intervention | -7 (-10.3, -3.6) | -2.3 (-6.2, 1.7) | -3.9 (-7.2, -0.7) | -0.2 (-3.8, 3.3) | -3.3 (-7.5, 0.8) | -2.7 (-6.4, 0.9) |
  Control | -2.4 (-5.1, 0.3) | -0.5 (-3.7, 2.6) | 0.7 (-2.6, 4.1) | 0.2 (-2.5, 2.9) | -1.9 (-4.8, 1.1) | Ref |
  p-valuea | 0.030 | 0.482 | 0.041 | 0.844 | 0.560 | 0.145 |